The research is accessment for mycoremediation technologies that can reduce contaminants present in agricultural manure waste streams, which have become a considerable threat to public health and overall food safety. Recent work in the area of mycoremediation has shown that certain white rot fungi (WRF) are capable of killing bacteria present in manure waste streams. In addition, these WRF are able to degrade antibiotics. sulfamethazine was tested in the batch study. Sulfamethazine are used for therapeutic treatment of intestinal and respiratory infections and for growth promotion in cattle, sheep, swine, and poultry. Previous research reported sulfamethazine concentration as high as 40 mg kg-1 in liquid manure from swine. The preliminary data support that the WRF, Pleurotus ostreatus, in bioreactors can reduce E.coli in dairy manure and degrade a pharmaceutical in a non-sterile bioreactor. The goals of this research are to optimize fungal bioreactor properties, to evaluate the predation/degradation behavior of the WRF, and efficiently degrade antibiotic contaminants in dairy manure.