Enhancing knowledge of the impact of air quality parameters and meteorological factors on SARS-CoV-2 transmission in various parts of the world is necessary. The aim of this project is to examine the effects of air pollution and meteorological parameters on the occurrence of SARS-CoV-2 cases in the cities of Turkiye. Within the scope of this research, air quality data (PM2.5, PM10, O3, SO2, CO) and meteorological data (temperature, humidity, precipitation, and wind intensity) were obtained from authorities (The Ministry of Health, The Ministry of Environment, City and Climate Change, and General Directorate of Meteorology) and investigated by the geographic information systems program. The findings of this study provide valuable data and information to decision-makers who may implement a variety of strategies to reduce air pollution in the regions with higher risks and prevent the adverse effects of a future pandemic on public health and economy.